The main research activity of T.O. Prikhna connected with the development of new ceramic materials having the necessary set of physicochemical characteristics – their synthesis, sintering, study of structure, properties and practical application. Over the years under her leadership and with her direct participation, a number of materials with a unique set of functional characteristics have been developed and researched, including high-temperature superconductors in the form of massive blocks, wires, thin films and Josephson junctions, materials based on MAX phases in the form of massive materials and coatings, single crystals of aluminum dodecaborides, massive materials based on refractory and shock-wave-resistant borides, carbides, nitrides and silicides, as well as nano- and micropowders of metals and their oxides and carbides, heavy and hard alloys made by electroerosive dispersion method. In her scientific works Prikhna TO studies the regularities of consolidation and synthesis of ceramic materials in a wide range of pressures and temperatures, using high quasi-hydrostatic pressures transmitted through solid media, isostatic gas pressures, hot pressing, spark plasma sintering, pressureless and vacuum sintering, magnetron and vacuum-arc evaporation methods. She specializes in the study of the structure of materials by scanning electron microscopy and Auger spectroscopy, as well as a comprehensive study of superconducting, electromagnetic, mechanical properties, chemical and mechanical resistance in reducing and oxidizing media in a wide range of temperatures.